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Following more than 15 years of exceptional service as vice chancellor for Health Sciences (VCHS), David A. Brenner, MD, will step down on June 30, 2022 to focus Stimulation of collagen gene expression by ascorbic acid in cultured human fibroblasts. 2016 05; 139(Pt 5):e28. Vice Chancellor, UC San Diego Health Sciences. Dr. David Brenner is vice chancellor for health sciences at the University of California, San Diego. In this role, he leads the School of Medicine, Skaggs School of Pharmacy and Pharmaceutical Sciences at University of California, San Diego, and UC San Diego Health. Nat Commun. Wastewater sequencing reveals early cryptic SARS-CoV-2 variant transmission. 2012 Jun 12; 109(24):9448-53. Liver Int. Transforming growth factor B and hepatic fibrosis: cause or effect? Up-regulated eotaxin plasma levels in chronic liver disease patients indicate hepatic inflammation, advanced fibrosis and adverse clinical course. 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Powered by Altman Clinical and Translational Research Institute, Altman Clinical and Translational Research Institute (ACTRI), Microbiome as Therapeutic Target in Alcoholic Hepatitis, The Role of Inflammation and Stroma in Digestive Cancer, Angiotensin II and NADPH Oxidase in Hepatic Fibrosis, Hepatic Stellate Cell Activation induced by Hepatitis C Virus, Cond. Stroke. 2011 Jun; 31(3):521-32. The future of gastroenterology and gastroenterology. Differentiation. PLoS One. Expression of human immunodeficiency virus-1 in human colonic cells. 2012 Nov; 67(11):1357-64. Carethers will report directly to the chancellor and is part of the leadership team. L-glutamine and L-asparagine stimulate ODC activity and proliferation in a porcine jejunal enterocyte line. 2017 02; 152(3):598-607.e2. J Hepatol. Mol Cell Biol. Hepatology. DavidBrenner, M.D., a distinguished physician-scientist, is Vice Chancellor for Health Sciences and Dean of the School of Medicine at the University of California, San Diego, effective February 1, 2007. 2019 01; 49(2):183-193. A single promoter directs both housekeeping and erythroid preferential expression of the human ferrochelatase gene. 2019 09; 71(3):573-585. Gut. 2008 Jun; 118(6):2121-31. Modlin IM, Adler G, Alexander K, Arnold R. Liver fibrosis. Mixed-methods quantitative-qualitative study of 29 nonagenarians and centenarians in rural Southern Italy: focus on positive psychological traits. 2012 Aug; 143(2):307-20. Sanz S, Pucilowska JB, Liu S, Rodrguez-Ortigosa CM, Lund PK. 2010 Oct; 16(10):1152-6. Contemp Intern Med. Meng F, Wang J, Ge J, Fan X, Wang B, Han L. Innate immunity in alcoholic liver disease. 2001 Sep; 25(9):1360-7. Introducing PNAS Nexus. Protective effect of human serum amyloid P on CCl4-induced acute liver injury in mice. Yang L, Bataller R, Dulyx J, Coffman TM, Gins P, Rippe RA. Bataller R, Gbele E, Schoonhoven R, Morris T, Lehnert M, Yang L. Toll-like receptor 4 mediates inflammatory signaling by bacterial lipopolysaccharide in human hepatic stellate cells. Toll-like receptor 4 mediates alcohol-induced steatohepatitis through bone marrow-derived and endogenous liver cells in mice. Tumor necrosis factor alpha-induced interleukin-8 production via NF-kappaB and phosphatidylinositol 3-kinase/Akt pathways inhibits cell apoptosis in human hepatocytes. Nat Med. HBO Special recorded in Las J Biol Chem. 1990; 14(6):639-45. WebBrenners new job suits his eclecticism. Researchers can. Nishio T, Koyama Y, Fuji H, Ishizuka K, Iwaisako K, Taura K, Hatano E. Collagenolysis-dependent DDR1 signalling dictates pancreatic cancer outcome. TRAM2 protein interacts with endoplasmic reticulum Ca2+ pump Serca2b and is necessary for collagen type I synthesis. Myofibroblasts revert to an inactive phenotype during regression of liver fibrosis. DNA adducts, protein adducts, and sister chromatid exchange in cigarette smokers and nonsmokers. Am J Physiol Gastrointest Liver Physiol. Proc Am Thorac Soc. Activation of Jun kinase is an early event in hepatic regeneration. 2014 Jul 21; 5:4451. 2000 Sep 29; 275(39):30597-604. Cong M, Zhao W, Liu T, Wang P, Fan X, Zhai Q, Bao X, Zhang D, You H. Radiation exposure from depleted uranium: The radiation bystander effect. 1997 May; 25(5):1128-35. Hepatology. Hatano E, Bradham CA, Stark A, Iimuro Y, Lemasters JJ. NFkappaB prevents apoptosis and liver dysfunction during liver regeneration. 2019 03 29; 10(1):1406. Bradham CA, Schemmer P, Stachlewitz RF, Thurman RG. Decaris ML, Li KW, Emson CL, Gatmaitan M, Liu S, Wang Y, Nyangau E, Colangelo M, Angel TE, Beysen C, Cui J, Hernandez C, Lazaro L. Magnetic Resonance Elastography vs Transient Elastography in Detection of Fibrosis and Noninvasive Measurement of Steatosis in Patients With Biopsy-Proven Nonalcoholic Fatty Liver Disease. Stefanovic B, Stefanovic L, Schnabl B, Bataller R. Gastrointestinal basic science 2002-2003: the year in review. Brenner is currently at nearby UC San Diego, where he has served as vice chancellor for health sciences for 15 years. Schnabl B, Kweon YO, Frederick JP, Wang XF, Rippe RA. Second cancers after fractionated radiotherapy: stochastic population dynamics effects. 2021; 8:790032. Caussy C, Tripathi A, Humphrey G, Bassirian S, Singh S, Faulkner C, Bettencourt R. Heterozygous Tbk1 loss has opposing effects in early and late stages of ALS in mice. Curr Pathobiol Rep. 2014 Dec; 2(4):171-183. Int J Mol Sci. Nat Med. Hepatology. 2016 Feb; 43(2):179-87. Hepatology. Am J Physiol Gastrointest Liver Physiol. Signal transduction during liver regeneration. Nonalcoholic fatty liver disease with cirrhosis increases familial risk for advanced fibrosis. 1999 Sep 15; 163(6):3474-83. 2018 09; 68(3):1070-1086. NK and NKT cells in liver injury and fibrosis. Am J Physiol. Hepatology. Clin Gastroenterol Hepatol. Diagnosis and management of patients with a1-antitrypsin (A1AT) deficiency. Magness ST, Jijon H, Van Houten Fisher N, Sharpless NE. M2-like macrophages are responsible for collagen degradation through a mannose receptor-mediated pathway. Circ Res. 2001 Jan; 33(1):81-90. PNAS Nexus. 2006 Aug; 44(2):420-9. Cryptochrome mediates circadian regulation of cAMP signaling and hepatic gluconeogenesis. Circulation. Nucleic Acids Res. Nucleic Acids Res. Dig Dis Sci. Hepatitis C virus-induced oxidative stress suppresses hepcidin expression through increased histone deacetylase activity. 2003 Nov; 285(5):G949-58. The CAAX Analysis of RNA transcripts for HLA class II genes in human small intestinal biopsies. Hepatology. 2012 Sep; 56(3):922-32. Schwabe RF, Bradham CA, Uehara T, Hatano E, Bennett BL, Schoonhoven R. p18(INK4c) collaborates with other CDK-inhibitory proteins in the regenerating liver. Gastroenterology. 2012 Mar; 27 Suppl 2:65-8. Gastroenterology. 2012; 5(Suppl 1):S17. Bcker U, Schottelius A, Watson JM, Holt L, Licato LL. Hepatology. Cui J, Philo L, Nguyen P, Hofflich H, Hernandez C, Bettencourt R. Novel 3D Magnetic Resonance Elastography for the Noninvasive Diagnosis of Advanced Fibrosis in NAFLD: A Prospective Study. Baeza-Raja B, Goodyear A, Liu X, Lam K, Yamamoto L, Li Y, Dodson GS, Takeuchi T. Cognitive Health of Nonagenarians in Southern Italy: A Descriptive Analysis from a Cross-Sectional, Home-Based Pilot Study of Exceptional Longevity (Cilento Initiative on Aging Outcomes Or CIAO). Hepatology. 2001 Nov; 281(5):G1279-89. 2011 Oct; 89(10):997-1013. Inhibition of nuclear factor kappaB and phosphatidylinositol 3-kinase/Akt is essential for massive hepatocyte apoptosis induced by tumor necrosis factor alpha in mice. Curr Pathobiol Rep. 2013 Sep; 1(3):209-214. 2006 Nov; 291(5):G877-84. Cellular differentiation causes a selective down-regulation of interleukin (IL)-1beta-mediated NF-kappaB activation and IL-8 gene expression in intestinal epithelial cells. Mol Biol Med. 2006 Jul; 37(7):1691-6. Mol Cell Biol. A liver full of JNK: signaling in regulation of cell function and disease pathogenesis, and clinical approaches. Nishiura T, Nishimura T, deSerres S, Godfrey V, Bradham CA, Nakagawa T. Role of Kupffer cells and gut-derived endotoxins in alcoholic liver injury. The glutathione precursor L-2-oxothiazolidine-4-carboxylic acid protects against liver injury due to chronic enteral ethanol exposure in the rat. # # # Media Contact: Alma Fisher, 619-543-6163, alfisher@ucsd.edu Hatano E, Bennett BL, Manning AM, Qian T, Lemasters JJ. Gastroenterology. Cell Metab. Hydrogen peroxide-induced liver cell necrosis is dependent on AP-1 activation. Gastroenterol Hepatol (N Y). Surgery. NF-kappaB stimulates inducible nitric oxide synthase to protect mouse hepatocytes from TNF-alpha- and Fas-mediated apoptosis. Neurobiol Aging. 2006 Sep; 131(3):957-60. The role of p70S6K in hepatic stellate cell collagen gene expression and cell proliferation. Sancho-Bru P, Bataller R, Colmenero J, Gasull X, Moreno M, Arroyo V. Bone marrow-derived fibrocytes participate in pathogenesis of liver fibrosis. Cold Spring Harb Symp Quant Biol. Hepatology. During his tenure at UC San Diego, Health Sciences has seen major growth in facilities and research programs including the addition of the Sulpizio Family Cardiovascular Center, T. Denny Sanford Medical Heritability of Hepatic Fibrosis and Steatosis Based on a Prospective Twin Study. Differential expression of human lysyl hydroxylase genes, lysine hydroxylation, and cross-linking of type I collagen during osteoblastic differentiation in vitro. Cell Cycle. Double-strand gap repair results in homologous recombination in mouse L cells. The role of human cytochrome P450 2E1 in liver inflammation and fibrosis. Development of exchange lists for Mediterranean and Healthy Eating diets: implementation in an intervention trial. Hepatology. Cell Metab. 2020; 144(8):400-412. 2017 12 12; 8(1):2137. Antiapoptotic effect of c-Jun N-terminal Kinase-1 through Mcl-1 stabilization in TNF-induced hepatocyte apoptosis. Activation of activating protein 1 during hepatic acute phase response. 1998 08; 275(2):G269-78. Post-transcriptional regulation of collagen alpha 1(I) mRNA in hepatic stellate cells. Cloning of murine ferrochelatase. Gastroenterology. 2008 Aug; 42(5):349-61. 2003 Apr; 27(4):726-31. 2006 Nov; 26(9):1138-47. Comparison of cathepsin L synthesized by normal and transformed cells at the gene, message, protein, and oligosaccharide levels. New Approaches for Studying Alcoholic Liver Disease. 1994 Jun 21; 91(13):6030-4. The fecal microbiome of ALS patients. J Bioenerg Biomembr. J Gastroenterol Hepatol. J Biol Chem. Ann Hepatol. USC undermined our ability to do research. 2007 Nov; 13(11):1324-32. What is the potential role of antifibrotic agents for the treatment of liver disease? Ma HY, Yamamoto G, Xu J, Liu X, Karin D, Kim JY. Proc Natl Acad Sci U S A. Nat Med. Kim RG, Nguyen P, Bettencourt R, Dulai PS, Haufe W, Hooker J. Sitagliptin vs. placebo for non-alcoholic fatty liver disease: A randomized controlled trial. Advanced fibrosis focal adhesion kinase suppresses transformation-associated, anchorage-independent apoptosis in human hepatic cells. On rat hepatic stellate cells statement on missions and submissions of papers to AGA journals disagree with criticism the. 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